In recent decades, the relevant role of the microbiota in human health has been revealed. In this sense, the Research and Development project GESTAHEALTH: “Towards a healthier gestation and lactation through the modulation of the microbiota in women” addresses the search for innovative solutions to prevent and/or treat women’s health problems during the pre-conceptive stage, pregnancy and lactation through the study of their microbiota and the use of probiotic strategies aimed at avoiding or reducing microbiota imbalances. These situations of dysbiosis, which particularly affect women during periods as important as pregnancy and lactation, can have repercussions not only on the health of the mother but also on the health of the baby.
Biosearch Life has been a pioneering company in the study of the microbiota in breast milk and with this new initiative it intends to continue advancing in this line, deepening, even more, in the knowledge of the different microbiotas associated with women.
Within the framework of the GESTA HEALTH project, different clinical studies will be carried out that will help to better understand the interaction between bacterial populations, as well as their interaction with the human organism. It is important to highlight that some of the studies that will be addressed in the project are aimed at finding natural and effective treatments based on probiotics, which would help reduce the use of antibiotics during periods as sensitive as pregnancy and lactation.
This strategy would be aligned with the recommendations of WHO and other official bodies to reduce the consumption of antibiotics and reduce the risk of multi-resistance generation in pathogens. The generation of multi-resistant pathogens is considered a major threat to global health as it is causing therapeutic treatments that were initially effective against certain diseases to become unsuccessful.
On the other hand, antibiotic treatments cause imbalances in the mother’s and baby’s microbiota, which can negatively affect the child’s colonization process.
The colonization of the baby by a balanced microbiote is key in its development and will impact throughout its life. An essential factor in the baby’s colonization is the mother’s own microbiota, which acts as an active source of bacteria for the baby. The GESTAHEALTH project will address the relationship between the mother’s microbiota and the child’s colonization process in order to study the factors involved and design intervention strategies in the mother that ensure the correct colonization of the baby.
The three-year project, with a total investment of €2.3 million, is supported by the Center for the Development of Industrial Technology (CDTI) through the granting of partially reimbursable aid co-financed by the European Regional Development Fund (ERDF) through the Plurirregional Operational Programme of Spain 2014-2020 (IDI-20181226).
On the other hand, it is worth mentioning the collaboration of important research groups from different universities in Spain such as the Complutense University of Madrid, the University of Granada and the University of Barcelona, as well as health services and hospitals.
Following the completion of the CARMENTA project: “New strategies for technological innovation aimed at children’s and women’s health and well-being” (approved in the 2015 call of the Feder Interconecta programme), GESTA HEALTH is a new example of Biosearch Life’s commitment to children’s and women’s health, two lines of research in which the company has been working intensively in recent years to consolidate itself as a global benchmark.